Sickle Cell Disease Sickle Cell Disease is a group of hereditary blood disordrs affecting Red Blood Cells, with high morbidity and death rates. There are different types of sickle cell disease including sickle cell hemoglobin C (SC) disease, sickle cell hemoglobin D (SD) disease, and sickle cell beta-thalassemia which are less severe forms of sickle cell disease. Sickle cell anemia is a more severe form. According to World Health Organization, it is the most prevalent genetic disease in the WHO African Region. In many countries, 10%–40% of the population carries the sickle-cell gene resulting in estimated SCD prevalence of at least 2%. Normal Red Blood Cells are biconcave discs and are pliable or flexible which enables them deform without rupturing and squeeze through narrow blood capillaries. Red Blood Cells live up to about one hundred and twenty (120) days after which they are destroyed by macrophages in the spleen, liver or red bone marrow and their components recycled to